Unmanned operations pose a huge challenge to the integration of human and machine. On one hand, the unique operational mode and environment of unmanned operations present severe challenges to the abilities and capabilities of natural persons. The operational speed of highly intelligent operation systems and massive data information increasingly challenge the reaction and decision-making of human beings, and the virtual, remote and isolated operational environment greatly influences human psychological mentality. On the other hand, although the high intelligence of the machine is conducive to the better use of potential operational capabilities, it also inevit- ably brings the risk of incontrollable war and morality deterioration. To address the two-dimensional human-machine challenge and realize the deep human-machine integration, on one hand, we must use enhancement technology to accelerate improving human capabilities from physical, physiological, and psychological levels; on the other hand, we must strengthen the ethical safety design of robots, stick to the bottom line of human control over robots, and avoid the moral risks of pushing robot out of control and leading to “dehumanization” of war.